María no se siente bien y va al doctor

What does “¿qué te pasa?” mean in Spanish?

¿Qué te pasa? is how you ask “What’s wrong?” or “What’s the matter with you?” It comes from the verb pasar (“to happen”), so word for word it is “what happens to you?” In this clip a worried husband asks the sick María ¿qué te pasa? You can swap the little word to ask about other people: ¿qué le pasa a María? (“what’s wrong with María?”).

The pattern is ¿qué + (me/te/le/nos) + pasa? — ¿qué me pasa? (“what’s wrong with me?”), ¿qué les pasa? (“what’s wrong with them?”). The clip uses both ¿qué le pasa a María? and ¿qué te pasa?, a neat way to hear the same question pointed at different people.